
The Purdue Boilermakers hit the road to take on the Houston Cougars in a battle between two top-tier programs. Purdue has struggled away from home and against the spread (ATS), while Houston remains one of the toughest defensive units in the country, especially at home. Despite this, the spread is wide, giving Purdue bettors reason to take a closer look. In this article, we’ll break down the Purdue vs Houston predictions using data-driven analysis from Rithmm’s AI model.
Purdue enters this game with a 2-3 ATS record in their last five and has failed to cover in both road appearances. Their offensive ceiling is high, but they’ve lacked consistency against strong defensive teams. Houston, on the other hand, is 3-2 ATS overall and has covered in three of their last five at home. Their physical defense and methodical tempo pose a serious challenge for visiting teams.
When reviewing Purdue vs Houston picks, Houston is the better overall team, but Purdue’s offensive potential and the sizable spread make them an intriguing underdog play.
Houston is favored to win at home, and Rithmm’s model supports this with a projected score of Houston 69.3 – Purdue 63.5. The Cougars are consistently tough to beat on their home floor, but with an 8.5-point spread, the Boilermakers have room to cover if they can get their offense rolling.

These stats help inform the Purdue vs Houston predictions and reveal both value and risk on the underdog side.

Rithmm’s AI model projects a final score of:
Houston 69.3 – Purdue 63.5
With Purdue catching +8.5, the model recommends taking the Boilermakers to cover with a 55.3% win probability. These Purdue vs Houston best bets present a moderate edge for those siding with the road team in a tough environment.
While the model shows Houston with a strong chance of winning outright, Purdue still holds potential value on the spread. A win may be unlikely, but keeping it within single digits is well within range if their offense shows up.

After reviewing Purdue vs Houston predictions, picks, and model insights, the most value lies in the underdog. While Houston should win at home, the spread gives Purdue enough cushion to stay within the number.
Best Bet: Purdue +8.5
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