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Giants vs Astros: Predictions, Picks, & Best Bets - MLB

Giants vs Astros Predictions and Best Bets

April 2, 2025

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The San Francisco Giants take on the Houston Astros in a matchup between two teams headed in opposite directions based on recent trends. The Giants are red hot against the spread, while the Astros continue to struggle both at home and as a favorite. In this article, we’ll break down the latest Giants vs Astros predictions using Rithmm’s AI-powered betting model and performance trends.

Preview of Giants vs Astros Prediction

San Francisco has been on a tear, covering the spread in four of their last five games, all on the road. On the other hand, Houston has failed to cover in four of their last five games and continues to underperform at home. With both recent form and momentum favoring the Giants, Giants vs Astros picks lean toward the underdog staying within the number.

Who is Favored to Win Giants vs Astros?

While the betting market slightly favors Houston, Rithmm’s model projects a different outcome. The AI model predicts a Giants 5.0 – Astros 4.0 final score. Based on this projection, San Francisco is not only a strong play on the run line but also a potential moneyline value bet.

Giants vs Astros History and Betting Trends

  • Giants are 4-1 ATS in their last 5 games
  • Giants are 4-1 ATS on the road
  • Giants are 2-1 ATS as an underdog
  • Astros are 1-4 ATS in their last 5 games
  • Astros are 1-4 ATS at home
  • Astros are 1-3 ATS as a favorite

These trends further support the edge in the current Giants vs Astros predictions.

Model Used for Giants vs Astros Best Bets

Rithmm’s MLB AI model forecasts:

  • Giants 5.0 – Astros 4.0

The best bet from the model is Giants +1.5, which carries a 70.1% win probability at -156 odds. These Giants vs Astros best bets highlight strong value in backing San Francisco to cover the run line.

What Chance Do the Giants Have of Beating the Astros?

Although they’re underdogs, the Giants are the sharper side according to both AI modeling and recent trends. The predictive model gives the Giants a strong edge in terms of covering and even winning outright. The Astros' struggles as a home favorite make the Giants a dangerous opponent in this spot.

My Pick for Giants vs Astros

After reviewing the Giants vs Astros predictions, the best play is clearly the Giants on the run line. They’re covering consistently, playing strong baseball on the road, and face a Houston team that hasn’t figured things out yet. Expect another competitive effort from the Giants that makes them an ideal target for run line bettors.

Best Bet: Giants +1.5 (-156)

Explore More Giants vs Astros Prediction

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This AI sports betting analysis is just a glimpse of what you can expect when using Rithmm. Whether you’re looking to refine your betting strategy or want to explore in-depth data trends, Rithmm's AI tools for sports betting has all you need. Don't miss out on making more informed decisions—download the Rithmm app today for full access to our AI baseball predictions, MLB Computer Picks, AI Player Props, and custom sports betting models.

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